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KMID : 0806120160460030420
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대한간호학회지
2016 Volume.46 No. 3 p.420 ~ p.430
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Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer
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Oh Pok-Ja
Lee Jung-Ran
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Abstract
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Purpose: The purpose of this study was to test a hypothetical model of chemotherapy-related cognitive impairment (CRCI) and depressionin people with gastrointestinal cancer.
Methods: A purposive sample of 198 patients undergoing chemotherapy was recruited from November2014 to July 2015. The instruments were Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), Functional Assessmentof Chronic Illness Therapy-Fatigue (FACIT-F), and M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module. Data were analyzedusing descriptive statistics, correlation, and path analysis.
Results: CRCI was directly affected by cancer symptoms (ß=.19, p =.004) and fatigue(ß=.56, p <.001)(R 2=47.2%). Depression was directly affected by fatigue (ß=.48, p <.001) and CRCI (ß=.27, p <.001). However, The impactof cancer symptoms on depression was confirmed through the mediating effect of CRCI.
Conclusion: Results indicate that in patientswith gastrointestinal cancer undergoing chemotherapy along with the direct physiologic effects (fatigue, symptoms) of cancer treatmentmay have altered cognitive function leading to depression.
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KEYWORD
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Mild cognitive impairment, Neoplasm, Fatigue, Depression
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